The closest it got was save on exit, which helped a lot of people; though even then people would get impatient and slap Q to get out of it.
Excel and Word notably save backups which can be retrieved. Mostly autosave has been shifted so that it doesn't take an intermediate version in memory and store that.
If you were comfortable with it, you could add a Save sequence to a frequently used mapkey or create an AutoIt script to pop up a reminder every so often.