If your skeleton methodology is an issue in reusing parts in any different assembly then you should reexamine your policy. Personally I am not a fan of driving part geometry with a skeleton. That is my opinion in the work that I am involved with. Creo is such a powerful tool that many things can be controlled/driven in many ways, but that doesn't always mean it makes sense to use all of that power. There are times that the overhead from dealing with those constraints far outweighs the gain.
All of that being said, I would mirror the frame and reuse the other parts if there is no change needed in the geometry from one side to the other. If your other parts are tied to the skeleton, personally, I would break those dependencies.